Understanding the Impact of Vial Quality on Chromatographic Efficiency
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Aijiren Chromatography Vials: Quality, Consistency, and
Dec 13, 2019 · Craig Douglas, Vials Product Manager for Aijiren, talks through his passion for quality and the importance of selecting the right vial for your Chromatograph
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How Glass Vial Quality Affects Data Accuracy - Jun 08 2020
Jun 22, 2020 · Here, we discuss how the surface and composition of the glass vials used in laboratories can affect data output and accuracy, ultimately impacting research findings and patient care. We also provide key considerations to choose the best glass vial quality for analytical applications.
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[ WHITE PAPER ] - Waters Corporation
Typical method-related risks associated with vial quality include adsorption of analyte, appearances of unexpected or “ghost” peaks, ionic effects such as ion suppression or pH changes, mechanical effects (e.g., septa blocking the autosampler needle), and evaporation and chemical incompatibility caused by interactions between the septa/caps and
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A Holistic Approach of Extractables and - ScienceDirect
Nov 1, 2021 · Toxicology-Based Risk Assessments. Toxicology-based risk assessments were conducted based on the extractable profiles of the rubber-stoppered glass vials for the purpose of extractable compounds evaluation, selection, qualification, and finally determining the targeted compounds of toxicological concern as well as the concentration limits for leachables testing of the drug products.
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How to Get the Most Out of Your Conductivity Testing
Oct 21, 2021 · Best practices for sampling with DUCT vials are: Do not rinse vials prior to use. To avoid contamination, do not touch the inside of the vial, cap, or septa. Fill the DUCT vial once, completely full, with no headspace and avoid turbulent flow when filling the vial. Immediately cap the vial. Do not reuse DUCT vials.
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Aijiren.com/chem/sampleprep SAMPLE PREPARATION Aijiren.com
in chromatographic and obviously the spectroscopic analyses of many sample types, was omitted. Many of the techniques covered, however, such as ion exchange SPE, liquid-liquid extraction and microwave-assisted extraction are equally applicable to inorganic samples for further analysis by ion chromatography or for spectroscopic measurements. Preface
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Gas Chromatography - Chemistry LibreTexts
Aug 29, 2023 · Gas chromatography is a term used to describe the group of analytical separation techniques used to analyze volatile substances in the gas phase. In gas chromatography, the components of a sample are dissolved in a solvent and vaporized in order to separate the analytes by distributing the sample between two phases: a stationary phase and a
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Total Organic Carbon (TOC): Back to Basics | American
Oct 26, 2020 · Total organic carbon (TOC) and conductivity data are used in various applications to demonstrate equipment cleanliness, purified water chemical purity, process understanding, and process control. Not only do these analyses offer numerous quality and efficiency gains within a process but monitoring CGMP equipment and pharmaceutical grade water systems is mandated by regulatory organizations
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Process intensification in the biopharma industry: Improving
Jan 1, 2022 · The chromatographic yield values represent the ratio of IgG mass in the product fraction relative to the total mass of IgG recovered in all outlet fractions. 2.3. Analytics2.3.1. Product quantification and quality attributes. IgG concentrations in samples were quantified by size exclusion chromatography as described by Saballus et al. [35].
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HPLC Tips & Tricks: Optimizing Injection Volume - MilliporeSigma
Practically, it is easily done. Start with the smallest volume that your injector can reproducibly inject and keep doubling it until a max 3% of your column’s volume is reached. Then calculate the limit of detection and resolution dependence on injection volume. Be prepared for the need to accept a compromise between detection limit and
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The development and qualification of liquid adsorption
Aug 30, 2021 · In conclusion, this method is sensitive and reliable to compare the quality variance of commercial P188 and is suitable for routine quality control purposes. The application of this method could help in further understanding the Critical Material Attributes (CMA) that may affect the quality attributes of proteins in formulations.
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Frontiers | Purification of Modified Therapeutic Proteins
Aug 20, 2021 · During its manufacturing, the purification steps of the therapeutic agent are decisive to ensure the quality, effectiveness, potency, and safety of the final product. Due to the robustness, selectivity, and high resolution of chromatographic methods, these are recognized as the gold standard in the downstream processing of therapeutic proteins.
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Understanding the Impact of Vial Quality on Chromatographic
May 24, 2018 · An appropriate control strategy may comprise one or more elements of raw material, in-process and manufacturing controls. Additionally, understanding the role, if any, polysorbates play during stability will require knowledge of the criticality of the excipient, based upon its impact on CQAs due to variations in concentration and degradation level.
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Headspace sampling fundamentals, what is headspace | Aijiren
Headspace Sampling for GC – The Basics. Headspace sampling is a type of sample introduction technique for gas chromatography (GC) and gas chromatography-mass spectrometry (GC/MS). For headspace techniques, the gas layer, or the headspace above the sample in a vial, is analyzed as opposed to withdrawing a volume from within the sample layer
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12.4: Gas Chromatography - Chemistry LibreTexts
Sep 12, 2021 · Figure 12.4.2 shows a typical example of a packed column. Figure 12.4.2 . Typical example of a packed column for gas chromatography. This column is made from stainless steel and is 2 m long with an internal diameter of 3.2 mm. The packing material in this column has a particle diameter of 149–177 μm.
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