injection with rubber stopper hplc sampler vials
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Septum Selection Guide Vials and Closures - fishersci.com
PTFE Natural Red Rubber are moderately priced seals for GC and HPLC with good chemical properties. They are ideal for multiple injections due to high resealability, but not as easy to penetrate as PTFE/RR. Natural rubber septa are offered assembled into aluminum crimp seals. PTFE/Synthetic Red Rubber Septa: (PTFE/RR) PTFE/ Synthetic Red Rubber
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382 ELASTOMERIC CLOSURE FUNCTIONALITY IN INJECTABLE - USP
within scope include 1) a stopper mechanically sealed to a vial or bottle; 2) a plunger stopper in contact with the wall of a syringe or cartridge (under ambient pressure or positive axial pressure); 3) a lined seal fitted to a cartridge; 4) a needle shield or tip cap fitted to a prefilled syringe (under
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Understanding Risks of Coring and Fragmentation of Rubber
Mar 2, 2021 · Stopper puncture testing also needs to be considered, especially if the closure system will be used in a multi-dose application. The piercing of a rubber stopper may cause so-called “fragments” or “cores,” i.e., rubber particles that may pose risk to the patient.
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Backflushing the needle seat of the Aijiren Vialsampler
Disconnect the seat capillary from port 5 in the injection valve and connect the needle seat capillary to port 6. The flow will go directly from the pump through the needle seat (make sure to work in bypass mode, use Figure 4 as a reference). Figure 4. Injection valve ports, standard configuration. Connections: 1 - From pump 2 - To metering device
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Serum Vials and Closures | Fisher Scientific
Autosampler Vials, Caps, and Closures Chromatography and Mass Spectrometry Reagents Chromatography Columns and Cartridges Chromatography Syringes Chromatography Water Gases and Gas Accessories Paper Chromatography Products Solid Phase Extraction Products TLC Products Chemicals Chemicals Acids Analytical and Chromatography Bases
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Coring and Fragmentation May Occur With Rubber Cap and Blunt
An induction dose of propofol was drawn through a disposable syringe attached to a blunt plastic needle to pierce the rubber stopper. After the needle was withdrawn, a dark object was seen at the bottom of the propofol vial. Upon close inspection, a cored piece of rubber from the vial’s rubber stopper was identified (Figure).
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Vial Stoppers: The Hidden Latex Risk in the Perioperative
One source of latex, however, still exists in the perioperative environment: rubber vial stoppers. Literature has demonstrated that piercing of a rubber stopper results in measurable quantities of latex in the vial as well as measurable latex antigens in blood after injection.
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Autosampler Vials, Inserts, and Closures | Fisher Scientific
Autosampler vials are usually made from clear or amber glass, both of which are highly inert. Amber glass helps protect more sensitive samples from exposure to UV light and radiation. Vial inserts are used to reduce the capacity of the vial to accommodate smaller samples. Typically 150 to 400µL in volume, they may be made of glass, plastic, or
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Lyophilization of Parenterals | FDA
The stopper is placed on top of the vial and is ultimately seated in the lyophilizer. Because different stoppering equipment is required, stoppers are sometimes placed on vials by operators rather
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Stoppers | Fisher Scientific
Stoppers Stoppers, also known as bungs, are used to give an airtight seal to laboratory flasks and test tubes by fitting tightly inside the neck of the container and preventing material from spilling. Stoppers can be made of glass, cork, rubber, or silicone.
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Avoiding unconscious injection of vial-derived rubber
Jun 1, 2021 · This study shows the occurrence of rubber particles in the injection fluid in 10–33% of the cases, when standard needles are used for the aspiration of drugs. We therefore recommend using industrially prefilled syringes, filter needles or removing the rubber stopper before withdrawing drugs from vials for intra-articular injections.
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Septa Selection Tool | Thermo Fisher Scientific - NO
The septum you choose for your autosampler vial can impact sample evaporation, sample security, needle bending and blockages, and instrument down time. Don’t let the complexities of septa selection slow you down. Use the simple online Thermo Scientific SureSTART Selection Guide to find the right septa and vial for your analysis.
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Autosampler Vial Caps and Closures | Fisher Scientific
Headspace vials are available in clear or amber glass with a round or flat base, a crimp seal with a beveled or square edge finish, or with a screw-thread finish. Headspace vials, septum, and caps can be purchased in various quantities separately or together as convenience kits to fit your laboratory needs.
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Stopper Pop Up During Fill Finish Operations - West
Jul 15, 2021 · Stopper Pop Up During Fill Finish Operations. Liquid injectable drugs can be contained in a pre-filled syringe system, a cartridge-based system, or a vial-based system (with a rubber stopper and seal). For a vial-based system, the drugs first are aseptically filled into glass or polymer vials. During the subsequent Fill & Finish operations, the
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Troubleshooting HPLC autosamplers - Wiki - Consumables
HPLC systems make it possible to perform high-resolution, fast separations with ease. A typical system consists of a pump, detector, and autosampler. In this article, we are going to look at how to optimize your HPLC system, looking specifically at troubleshooting HPLC autosamplers.
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